P003 The Effect of Centella Asiatica on Inactive Frequency and Movement Distance in Insomnia Zebrafish (Danio rerio) Larvae Model
نویسندگان
چکیده
Abstract Introduction Insomnia is a global health problem. Zebrafish (Danio rerio) an ideal model for studying sleep disorder due to its diurnal cycle. Centella Asiatica (CA) thought have anti-insomnia effect, but mechanism not clearly understood. The aim of this study evaluate the effect CA on insomnia zebrafish larvae by observing parameters including inactive frequency and movement distance. Methods This experimental divided into five groups consisting control group, group with 24 hours light exposure 7 days, concentration 2.5, 5, 10 µg/mL. Observation larval was carried out 6, dpf (day post fertilization) during 30 minutes before after turning off exposure. Results There were significant differences between normal all treatment addition distance in dark conditions (p<0.05). Discussion showed that has effect. can improve quality increasing shortening Keywords Asiatica, zebrafish, frequency,
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ژورنال
عنوان ژورنال: Sleep advances
سال: 2022
ISSN: ['2632-5012']
DOI: https://doi.org/10.1093/sleepadvances/zpac029.076